Low-dose naltrexone bottle and oxytocin nasal spray
Prescribed by
U.S.-licensed clinicians
Compounded by a
Licensed pharmacy
Charged only
If prescribed
Treatment 01: low-dose naltrexone, LDN for immune and endorphin signaling. Treatment 02: oxytocin, for stress response.
Two pathways, one plan. Complementary roles for persistent low energy. Immune signaling, endorphin signaling, stress response.
Where each treatment acts. Immune signaling: LDN may calm activity linked to inflammation. Endorphin signaling: LDN may prompt your own endorphin signaling. Stress response: oxytocin acts on how you respond to stress.
Myth: more sleep will fix it. Fact: inflammation and stress can sap energy too.
Low-dose naltrexone bottle and oxytocin nasal spray
Prescribed by
U.S.-licensed clinicians
Compounded by a
Licensed pharmacy
Charged only
If prescribed
Treatment 01: low-dose naltrexone, LDN for immune and endorphin signaling. Treatment 02: oxytocin, for stress response.
Two pathways, one plan. Complementary roles for persistent low energy. Immune signaling, endorphin signaling, stress response.
Where each treatment acts. Immune signaling: LDN may calm activity linked to inflammation. Endorphin signaling: LDN may prompt your own endorphin signaling. Stress response: oxytocin acts on how you respond to stress.
Myth: more sleep will fix it. Fact: inflammation and stress can sap energy too.
RX BUNDLE
CLINICIAN-PRESCRIBED

Energy & Recovery Bundle

Low energy rarely has one cause. Low-dose naltrexone (LDN) and oxytocin nasal spray act on different drivers, with a dosing plan your clinician adjusts to you.

4.7

|

20,000+ patients served

LDN

Immune signaling

LDN

Endorphin support

Oxytocin

Stress recovery

clinician-led

Evaluated for you

CHOOSE YOUR TREATMENT

CHOOSE YOUR TREATMENT

You’re only charged for what your clinician prescribes.

Start my evaluation

Free standard shipping

Prescribed by U.S.-licensed clinicians

Charged only if prescribed

Cancel or pause anytime

Why these two together

Low energy rarely has a single driver. Low-dose naltrexone (LDN) may calm immune activity linked to inflammation and is thought to boost your own endorphin signaling. Oxytocin nasal spray acts on how your body responds to and recovers from stress. Different pathways, paired so your clinician can address more than one at a time.

Who it’s for

Adults with persistent low energy alongside stress, poor sleep, or pain. Your clinician reviews your history and medications to decide whether one or both treatments fit.

Who it’s not for

People who take or plan to take opioid pain medication, and people who are pregnant or breastfeeding. Your clinician screens for other conditions during your evaluation.

How you start

Both treatments ship together. Your clinician creates a personalized dosing plan and can adjust it as you go.

Why one fix rarely works

Energy has more than one driver.

Low energy is rarely just about sleep. These three often show up together, which is why a single fix so often falls short.

  1. 01

    Ongoing inflammation

    Low-grade inflammation that doesn’t switch off is linked to feeling worn down.

  2. 02

    Pain and mood

    Endorphins help regulate how you feel pain and mood, and both shape your energy.

  3. 03

    Stress that doesn’t let up

    When your stress response never fully resets, it’s hard to feel recharged.

LDN and oxytocin each act on a different one.Here’s how

The science, simply

Two treatments,
two systems.

LDN for inflammation and endorphins, oxytocin for stress. One plan.

Low-dose naltrexone (LDN)

Immune & endorphin signalingImmune & endorphin

Low-dose naltrexone (LDN) · Started together

At low doses, naltrexone briefly blocks opioid receptors, which is thought to prompt your body to make more of its own endorphins. It may also calm immune activity linked to inflammation, one of the things tied to feeling run down.

Oxytocin nasal spray

Stress responseStress response

Oxytocin nasal spray · Started together

Oxytocin acts on its own receptors, in a pathway involved in how your body responds to stress and recovers from it. Stress that doesn’t let up is a common drain on energy.

Started togetherProposed pathways

Low-dose naltrexone (LDN)

At low doses, naltrexone briefly blocks opioid receptors, which is thought to prompt your body to make more of its own endorphins. It may also calm immune activity linked to inflammation, one of the things tied to feeling run down.

Oxytocin nasal spray

Oxytocin acts on its own receptors, in a pathway involved in how your body responds to stress and recovers from it. Stress that doesn’t let up is a common drain on energy.

What to expect

A plan that adjusts to your energy.

Any change in energy builds gradually, so judge it over weeks, not days. As you go, your clinician can adjust your dose based on how you’re feeling.

  1. (01)

    Your baseline

    Share your health history and where your energy, stress, sleep and pain are today. Your payment method is saved, not charged.

  2. (02)

    Your plan

    A U.S.-licensed clinician decides whether one or both treatments fit and sets a personalized dosing plan.

  3. (03)

    Both arrive together

    Your treatments ship in one box with your clinician’s instructions. Changes build gradually, so judge it over weeks, not days.

  4. (04)

    Your plan adjusts

    Tell your care team how your energy is going, anytime. Your clinician can adjust your dose or stop one treatment, and you can pause or cancel anytime.

    Repeats as you go

Common questions

When might I notice a difference?

It varies from person to person. Some people notice changes within the first weeks, others take longer, and not everyone responds. Let your care team know how it’s going, and your clinician can adjust your plan.

How do I take each treatment?

LDN is taken by mouth and oxytocin is a nasal spray. Your clinician sets the dose and timing for each in your personalized plan, and the instructions come in your box.

What are the side effects?

With LDN, the most commonly reported are vivid dreams, trouble sleeping and headaches, usually early on. With oxytocin nasal spray, nasal irritation and headaches are reported. Tell your care team about any side effects; your clinician can adjust your plan.

Can I use this if I take opioid pain medication?

No. LDN blocks the effects of opioid medications, so this bundle isn’t a fit. Talk to your clinician about other options.

Can I stop one, or start with just one?

Yes. If you stop one, or you’re only eligible for one, the bundle ends and that treatment continues at its standalone price. You’re never charged for a treatment you aren’t prescribed.

What if it doesn’t work for me?

Message your care team. Your clinician can adjust your dose, change your plan, or stop a treatment. You can pause or cancel anytime.

How much does it cost?

The bundle starts at $180/month, billed quarterly. LDN alone is $65/month and oxytocin nasal spray alone starts at $121/month on an annual plan. It’s cash pay.

When am I charged?

Only after your clinician prescribes. We save your payment method at signup but don’t charge until a treatment is approved.

When might I notice a difference?

It varies from person to person. Some people notice changes within the first weeks, others take longer, and not everyone responds. Let your care team know how it’s going, and your clinician can adjust your plan.

How do I take each treatment?

LDN is taken by mouth and oxytocin is a nasal spray. Your clinician sets the dose and timing for each in your personalized plan, and the instructions come in your box.

What are the side effects?

With LDN, the most commonly reported are vivid dreams, trouble sleeping and headaches, usually early on. With oxytocin nasal spray, nasal irritation and headaches are reported. Tell your care team about any side effects; your clinician can adjust your plan.

Can I use this if I take opioid pain medication?

No. LDN blocks the effects of opioid medications, so this bundle isn’t a fit. Talk to your clinician about other options.

Can I stop one, or start with just one?

Yes. If you stop one, or you’re only eligible for one, the bundle ends and that treatment continues at its standalone price. You’re never charged for a treatment you aren’t prescribed.

What if it doesn’t work for me?

Message your care team. Your clinician can adjust your dose, change your plan, or stop a treatment. You can pause or cancel anytime.

How much does it cost?

The bundle starts at $180/month, billed quarterly. LDN alone is $65/month and oxytocin nasal spray alone starts at $121/month on an annual plan. It’s cash pay.

When am I charged?

Only after your clinician prescribes. We save your payment method at signup but don’t charge until a treatment is approved.

Ready when you are.

Charged only if prescribed. Cancel or pause anytime.

“…helped me make up my own mind as to what molecule I want to start with… followed up with scientific literature I was hoping to see on LDN before starting a trial.”

Raz R. · LDN patient, Trustpilot review
A Healthspan shipment box

Energy & Recovery Bundle

Starting at
$180/mo$200/mo10% OFF
  • Evaluation by a U.S.-licensed clinician
  • LDN and oxytocin, shipped together
  • 90-day supply, free standard shipping
  • Charged only for what’s prescribed
  • Cancel or pause anytime

Low-dose naltrexone and oxytocin are prescription medications available only after evaluation by a licensed clinician, who determines whether treatment is appropriate. Compounded medications are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness, or quality. Use of these medications for the symptoms described on this page is off-label. This page is educational and not medical advice; individual results vary.