Rapamycin
Rapamycin (Sirolimus) targets mTORC1, one of the body’s core longevity regulators, to activate autophagy, clear damaged cells, and restore cellular balance. This supports strength, recovery, and long term resilience from the inside out.
Reduces chronic inflammation that contributes to joint stiffness and pain.
Boosts your body’s ability to recover and stay energized over time
Enhances insulin sensitivity and energy regulation for better long-term health.
Our patients see an average reduction in biological age of 8 years
Go beneath the surface of aging
Dosing is Everything.
Inhibits mTORC1 and Activates Autophagy
Rapamycin selectively inhibits mTORC1, a key longevity regulator, activating autophagy to clear out damaged components and promote cellular renewal.
Supports Mitochondrial Health
Autophagy enhances mitophagy—the removal of faulty mitochondria—improving cellular energy output. mTOR and AMPK signaling together help maintain mitochondrial longevity.
Balances AMPK and mTOR
Rapamycin modulates the AMPK and mTOR axis to rebalance growth and repair processes. This balance is essential for healthy metabolism, inflammation control, and longevity.
The highest standards of care
Quantifies the active pharmaceutical ingredient to ensure it meets labeled strength and therapeutic specifications.
Evaluates for the presence of viable microorganisms in accordance with USP 71 to confirm aseptic integrity.
Measures the formulation’s pH to ensure chemical stability and compatibility with physiological conditions.
Assesses for pyrogenic bacterial endotoxins using USP <85> standards to ensure patient safety upon administration.
To affect longevity, we must understand its pathways
Cellular senescence & inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Mitochondrial Function & Mitophagy
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Insulin/IGF-1 Modulation
Improves insulin sensitivity and regulates IGF-1 signaling, supporting metabolic health and biological age control.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Cellular senescence & inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Mitochondrial Function & Mitophagy
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Insulin/IGF-1 Modulation
Improves insulin sensitivity and regulates IGF-1 signaling, supporting metabolic health and biological age control.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Cellular senescence & inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Mitochondrial Function & Mitophagy
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Insulin/IGF-1 Modulation
Improves insulin sensitivity and regulates IGF-1 signaling, supporting metabolic health and biological age control.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Cellular senescence & inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Mitochondrial Function & Mitophagy
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Insulin/IGF-1 Modulation
Improves insulin sensitivity and regulates IGF-1 signaling, supporting metabolic health and biological age control.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Included with your Rapamycin Protocol
When you sign up with us we work together to create a personalized protocol using the latest innovative medicine, practicing physicians, and flexible care based around real data and plan-included testing.
When you sign up with us we work together to create a personalized protocol using the latest innovative medicine, practicing physicians, and flexible care based around real data and plan-included testing.
Hear from our patients
Nothing short of miraculous...
Osteoarthritis pains improved 97%, pain in my neck is gone! All this and Ive just entered week 4 of treatment with Rapamycin. Can hardly wait for week 8 to see how much more Ill be amazed!!
Paul Windhausen
My joint pain has got so much better.
I really appreciate how they review blood work with me and guide me through the process. My joint pain has got so much better. I am glad that they have figured a way to make Rapamycin more available
Stephanie
Labs, progress, and care. All dialed in.
Healthspan provides great care when prescribing Rapamycin alongside frequent lab tests and detailed progress monitoring
Jspflorida
(Featured In)
(Featured In)
Ahead of the field
“Really good quote about Healthspan goes here”
“Rapamycin... is at the leading edge of a generation of research trials.”
“Really good quote about Healthspan goes here”
“Rapamycin... is at the leading edge of a generation of research trials.”
“Really good quote about Healthspan goes here”
“Rapamycin... is at the leading edge of a generation of research trials.”
“Really good quote about Healthspan goes here”
“Rapamycin... is at the leading edge of a generation of research trials.”
Reviews
Happy with my protocol
I have been taking acarbose and rapamycin and have had no issues at all. As a matter of fact, I can tell you that my endurance in my running is way much better and my sleep has improved 100%. I am happy with my protocol!!! Thank you all!!!!
Getting my life back
I feel overall like my inflammation is almost gone! It's incredible! I am able to exercise more than before since my joints aren't hurting!! It's wonderful! Thank you so much. I'm getting my life back.
Nothing short of miraculous
Osteoarthritis pains improved 97%, pain in my neck is gone! All this and Ive just entered week 4 of treatment with Rapamycin. Can hardly wait for week 8 to see how much more Ill be amazed!!
Frequently asked questions
Your protocol includes a fully personalized dosing plan based on lab data, free biomarker testing, access to high-bioavailability rapamycin, and direct guidance from our clinical support team. You’ll also get access to a personalized dashboard to monitor results and track changes in biological age, mTOR activity, and more.
Yes. We only source from certified pharmacies and validate the bioavailability of every batch. Rapamycin absorption varies—so we use pharmacokinetic testing standards like Tmax and Cmax to select the most reliable formulations.
Your panel includes key metabolic, inflammatory, and longevity biomarkers—ApoB, hs-CRP, IGF-1, insulin sensitivity, liver function, and more. These help us assess autophagy activation, mTOR activity, and aging trends.
We prioritize generic rapamycin for its proven absorption profile (3x higher than compounded). Compounded formulations are available in special cases but are not our first-line approach.
When dosed intermittently and monitored by our team, rapamycin can be used safely for long-term healthspan support. Weekly protocols are designed to avoid mTORC2 inhibition and minimize immune suppression.
You’ll typically start with 3mg weekly and titrate up based on labs. Most patients stabilize between 5–8mg/week. All doses are taken once per week—not daily—to optimize autophagy and avoid continuous mTOR inhibition.
We strongly recommend labs for dose optimization and to track effects on mTOR, autophagy, and inflammation. Your labs are included at no additional cost.
You do not need a separate physician. Our clinical support team handles onboarding, optimization, and regular lab reviews to guide your journey.
Yes—rapamycin was originally developed as an immunosuppressant for organ transplant recipients. In that setting, it’s used at high, continuous doses that inhibit both mTORC1 and mTORC2, leading to broad immune suppression. In contrast, longevity protocols use low, intermittent doses designed to selectively inhibit mTORC1 only, while sparing mTORC2. This preserves immune function and instead promotes beneficial effects like autophagy activation, cellular repair, and inflammation reduction.
Rapamycin may not be suitable for individuals with uncontrolled infections, severely impaired immune systems, recent major surgeries, or those who are pregnant or breastfeeding. All protocols are reviewed by a physician to ensure safety based on your health profile.
Your protocol includes a fully personalized dosing plan based on lab data, free biomarker testing, access to high-bioavailability rapamycin, and direct guidance from our clinical support team. You’ll also get access to a personalized dashboard to monitor results and track changes in biological age, mTOR activity, and more.
Yes. We only source from certified pharmacies and validate the bioavailability of every batch. Rapamycin absorption varies—so we use pharmacokinetic testing standards like Tmax and Cmax to select the most reliable formulations.
Your panel includes key metabolic, inflammatory, and longevity biomarkers—ApoB, hs-CRP, IGF-1, insulin sensitivity, liver function, and more. These help us assess autophagy activation, mTOR activity, and aging trends.
We prioritize generic rapamycin for its proven absorption profile (3x higher than compounded). Compounded formulations are available in special cases but are not our first-line approach.
When dosed intermittently and monitored by our team, rapamycin can be used safely for long-term healthspan support. Weekly protocols are designed to avoid mTORC2 inhibition and minimize immune suppression.
You’ll typically start with 3mg weekly and titrate up based on labs. Most patients stabilize between 5–8mg/week. All doses are taken once per week—not daily—to optimize autophagy and avoid continuous mTOR inhibition.
We strongly recommend labs for dose optimization and to track effects on mTOR, autophagy, and inflammation. Your labs are included at no additional cost.
You do not need a separate physician. Our clinical support team handles onboarding, optimization, and regular lab reviews to guide your journey.
Yes—rapamycin was originally developed as an immunosuppressant for organ transplant recipients. In that setting, it’s used at high, continuous doses that inhibit both mTORC1 and mTORC2, leading to broad immune suppression. In contrast, longevity protocols use low, intermittent doses designed to selectively inhibit mTORC1 only, while sparing mTORC2. This preserves immune function and instead promotes beneficial effects like autophagy activation, cellular repair, and inflammation reduction.
Rapamycin may not be suitable for individuals with uncontrolled infections, severely impaired immune systems, recent major surgeries, or those who are pregnant or breastfeeding. All protocols are reviewed by a physician to ensure safety based on your health profile.