Acarbose
Support metabolic health and longevity by moderating blood sugar spikes, stimulating GLP-1, and optimizing the gut microbiome.
Enhances the microbiome and lowers inflammation—protecting vascular health and long-term resilience.
Reduces insulin resistance and boosts GLP-1 to support fat loss, appetite control, and glucose balance.
Slows carbohydrate digestion to prevent energy crashes, cravings, and metabolic stress after meals.
Master the science of metabolic stability
To affect longevity, we must understand its pathways
Insulin/IGF-1 Signaling
Acarbose inhibits gut enzymes that break down carbohydrates, reducing glucose absorption and insulin secretion. This decreases insulin/IGF-1 signaling, a pathway associated with lifespan extension when moderately inhibited.
Gut Microbiome Remodeling
Acarbose increases resistant starch that feeds beneficial gut bacteria, producing short-chain fatty acids (SCFAs) linked to longevity. This remodels the microbiome to reduce inflammation and promote healthspan.
Glycemic Control
Acarbose maintains stable blood glucose by slowing carbohydrate digestion, reducing glycation damage where sugar molecules harm proteins and accelerate aging-related cellular damage.
AMPK Activation
By reducing post-meal blood sugar spikes, Acarbose maintains a metabolic state that promotes AMPK activation, supporting autophagy and other processes associated with health and longevity.
GLP-1 Secretion
Acarbose promotes GLP-1 secretion, which slows gastric emptying and stimulates insulin release. GLP-1 provides longevity benefits through improved glucose metabolism and other mechanisms.
Mitochondrial Function
Acarbose reduces postprandial glucose spikes, helping decrease chronic inflammation and potentially delaying onset of inflammation-related age-related diseases.
Weight Control
Acarbose slows digestion to help maintain healthy weight and reduce caloric intake, acting as a caloric restriction mimetic—the most reliable intervention for lifespan extension.
Insulin/IGF-1 Signaling
Acarbose inhibits gut enzymes that break down carbohydrates, reducing glucose absorption and insulin secretion. This decreases insulin/IGF-1 signaling, a pathway associated with lifespan extension when moderately inhibited.
Gut Microbiome Remodeling
Acarbose increases resistant starch that feeds beneficial gut bacteria, producing short-chain fatty acids (SCFAs) linked to longevity. This remodels the microbiome to reduce inflammation and promote healthspan.
Glycemic Control
Acarbose maintains stable blood glucose by slowing carbohydrate digestion, reducing glycation damage where sugar molecules harm proteins and accelerate aging-related cellular damage.
AMPK Activation
By reducing post-meal blood sugar spikes, Acarbose maintains a metabolic state that promotes AMPK activation, supporting autophagy and other processes associated with health and longevity.
GLP-1 Secretion
Acarbose promotes GLP-1 secretion, which slows gastric emptying and stimulates insulin release. GLP-1 provides longevity benefits through improved glucose metabolism and other mechanisms.
Mitochondrial Function
Acarbose reduces postprandial glucose spikes, helping decrease chronic inflammation and potentially delaying onset of inflammation-related age-related diseases.
Weight Control
Acarbose slows digestion to help maintain healthy weight and reduce caloric intake, acting as a caloric restriction mimetic—the most reliable intervention for lifespan extension.
Insulin/IGF-1 Signaling
Acarbose inhibits gut enzymes that break down carbohydrates, reducing glucose absorption and insulin secretion. This decreases insulin/IGF-1 signaling, a pathway associated with lifespan extension when moderately inhibited.
Gut Microbiome Remodeling
Acarbose increases resistant starch that feeds beneficial gut bacteria, producing short-chain fatty acids (SCFAs) linked to longevity. This remodels the microbiome to reduce inflammation and promote healthspan.
Glycemic Control
Acarbose maintains stable blood glucose by slowing carbohydrate digestion, reducing glycation damage where sugar molecules harm proteins and accelerate aging-related cellular damage.
AMPK Activation
By reducing post-meal blood sugar spikes, Acarbose maintains a metabolic state that promotes AMPK activation, supporting autophagy and other processes associated with health and longevity.
GLP-1 Secretion
Acarbose promotes GLP-1 secretion, which slows gastric emptying and stimulates insulin release. GLP-1 provides longevity benefits through improved glucose metabolism and other mechanisms.
Mitochondrial Function
Acarbose reduces postprandial glucose spikes, helping decrease chronic inflammation and potentially delaying onset of inflammation-related age-related diseases.
Weight Control
Acarbose slows digestion to help maintain healthy weight and reduce caloric intake, acting as a caloric restriction mimetic—the most reliable intervention for lifespan extension.
Insulin/IGF-1 Signaling
Acarbose inhibits gut enzymes that break down carbohydrates, reducing glucose absorption and insulin secretion. This decreases insulin/IGF-1 signaling, a pathway associated with lifespan extension when moderately inhibited.
Gut Microbiome Remodeling
Acarbose increases resistant starch that feeds beneficial gut bacteria, producing short-chain fatty acids (SCFAs) linked to longevity. This remodels the microbiome to reduce inflammation and promote healthspan.
Glycemic Control
Acarbose maintains stable blood glucose by slowing carbohydrate digestion, reducing glycation damage where sugar molecules harm proteins and accelerate aging-related cellular damage.
AMPK Activation
By reducing post-meal blood sugar spikes, Acarbose maintains a metabolic state that promotes AMPK activation, supporting autophagy and other processes associated with health and longevity.
GLP-1 Secretion
Acarbose promotes GLP-1 secretion, which slows gastric emptying and stimulates insulin release. GLP-1 provides longevity benefits through improved glucose metabolism and other mechanisms.
Mitochondrial Function
Acarbose reduces postprandial glucose spikes, helping decrease chronic inflammation and potentially delaying onset of inflammation-related age-related diseases.
Weight Control
Acarbose slows digestion to help maintain healthy weight and reduce caloric intake, acting as a caloric restriction mimetic—the most reliable intervention for lifespan extension.
Included with Acarbose
When you sign up with us we work together to create a personalized protocol using the latest innovative medicine, practicing physicians, and flexible care based around real data and plan-included testing.
When you sign up with us we work together to create a personalized protocol using the latest innovative medicine, practicing physicians, and flexible care based around real data and plan-included testing.
Hear from our patients
Happy with my protocol
I have been taking acarbose and rapamycin and have had no issues at all. I can tell you that my endurance in my running is way better and my sleep has improved 100%. I am happy with my protocol!
Mariam Watson
Great experience with Healthspan
I had a great call reviewing my initial labs with Brandon Fell who was extremely knowledgeable and courteous. I’ve started the Rapamycin and Acarbose protocol, and I’m looking forward to seeing what my updated labs will show in a couple months!
Anthony Badillo
Labs, progress, and care. All dialed in.
Healthspan provides great care when prescribing Rapamycin alongside frequent lab tests and detailed progress monitoring
Jspflorida
Reviews
96 reviews
Healthspan is amazing!!!
Kristen was fantastic …she was kind, informative and professional. She helped me in my journey to Health and longevity! Thank you!!
Healthspan continues to be cutting edge
Healthspan continues to be cutting edge with regard to health and longevity. Brandon was knowledgeable and supportive. The details of the study were explained well and in detail.
Great experience with Healthspan
I’ve had a great experience with Healthspan. All of the representatives have been extremely responsive when sending messages on the portal, and I had a great call reviewing my initial labs with Brandon Fell who was extremely knowledgeable and courteous. I’ve started the Rapamycin and Acarbose protocol, and I’m looking forward to seeing what my updated labs will show in a couple months!
Frequently asked questions
Acarbose inhibits alpha-glucosidase enzymes, slowing digestion of carbohydrates. This helps manage blood sugar and reduces inflammation via gut microbiome modulation.
Take with the first bite of a carb-rich meal. Tablets can be swallowed or chewed. Your clinician will guide specific timing and dose.
By stabilizing glucose, enhancing GLP-1, remodeling the microbiome, and reducing inflammation, Acarbose mimics calorie restriction—a known longevity pathway.
Yes. Acarbose moderates glucose spikes and reduces cravings, supporting better appetite control and weight regulation over time.
Temporary GI symptoms like bloating, gas, or mild cramping. These often improve with continued use and proper dose titration.
Yes. Acarbose is most effective when taken before meals containing complex carbohydrates.
Yes. Acarbose is often used off-label in longevity protocols to improve metabolic and gut health, even in non-diabetics.
Yes. Acarbose works well alongside Metformin, SGLT2 inhibitors, and Rapamycin under clinical supervision.
Acarbose inhibits alpha-glucosidase enzymes, slowing digestion of carbohydrates. This helps manage blood sugar and reduces inflammation via gut microbiome modulation.
Take with the first bite of a carb-rich meal. Tablets can be swallowed or chewed. Your clinician will guide specific timing and dose.
By stabilizing glucose, enhancing GLP-1, remodeling the microbiome, and reducing inflammation, Acarbose mimics calorie restriction—a known longevity pathway.
Yes. Acarbose moderates glucose spikes and reduces cravings, supporting better appetite control and weight regulation over time.
Temporary GI symptoms like bloating, gas, or mild cramping. These often improve with continued use and proper dose titration.
Yes. Acarbose is most effective when taken before meals containing complex carbohydrates.
Yes. Acarbose is often used off-label in longevity protocols to improve metabolic and gut health, even in non-diabetics.
Yes. Acarbose works well alongside Metformin, SGLT2 inhibitors, and Rapamycin under clinical supervision.