Cellular Renewal Stack
Cycles two synergistic blends—Autophagy and AMPK—to clear damaged proteins, boost energy, and support metabolic resilience. Designed to activate key longevity pathways for healthier aging. The Cellular Renewal Stack combines the Autophagy Blend and AMPK Blend to enhance mitochondrial health, promote longevity, and sustain energy through targeted modulation of key pathways like mTOR and NAD+
Helps repair micro-damage and reduce soreness from physical exertion.
Enhances mitochondrial output for more consistent daytime energy.
Activates repair and renewal mechanisms that slow biological aging.
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Discover deeper cellular restoration
To affect longevity, we must understand its pathways
Insulin/IGF-1 Signaling
AMPK enhances insulin sensitivity by promoting glucose transporter movement to cell surfaces, lowering circulating glucose and insulin levels to reduce pancreatic stress and improve metabolic health.
Inflammatory & Oxidative Stress
AMPK downregulates pro-inflammatory pathways like NF-κB while complementary polyphenols provide antioxidants that reduce reactive oxygen species, maintaining tissue function and slowing age-related inflammation.
Lipid Metabolism
AMPK boosts fatty acid oxidation, pushing cells to utilize stored fats for energy. This leads to balanced triglyceride and cholesterol levels, benefiting cardiovascular health and reducing lipid-driven tissue damage.
Fasting-Mimetic Mechanisms
AMPK ingredients mimic caloric restriction's metabolic adjustments, prompting efficient energy store usage. This partial fasting effect supports healthy aging without requiring strict dietary limitations.
Autophagy & Cellular Cleanup
The Autophagy Blend contains quercetin phytosomes, spermidine, and L-ergothioneine to upregulate autophagy genes and pathways, activating the cell's recycling system to remove toxic aggregates and dysfunctional organelles.
mTOR Regulation
The blend modulates mTORC1 signaling to promote healthy balance between growth and repair phases, preventing excessive activation that speeds aging by prioritizing growth over necessary cellular maintenance.
NAD⁺ & Sirtuin Activation
Niacinamide supports NAD⁺ availability for sirtuin enzymes that maintain genomic stability, preserving efficient energy metabolism and facilitating DNA repair processes fundamental to healthy aging.
Mitochondrial Function
Antioxidant-rich ingredients reduce reactive oxygen species to protect mitochondrial membranes from oxidative damage, improving endurance, energy levels, and overall metabolic flexibility.
Inflammatory Pathway Control
Polyphenols and bioactive compounds moderate inflammatory pathways like NF-κB, reducing chronic "inflammaging" stress that erodes tissue function and accelerates cellular damage.
Insulin/IGF-1 Signaling
AMPK enhances insulin sensitivity by promoting glucose transporter movement to cell surfaces, lowering circulating glucose and insulin levels to reduce pancreatic stress and improve metabolic health.
Inflammatory & Oxidative Stress
AMPK downregulates pro-inflammatory pathways like NF-κB while complementary polyphenols provide antioxidants that reduce reactive oxygen species, maintaining tissue function and slowing age-related inflammation.
Lipid Metabolism
AMPK boosts fatty acid oxidation, pushing cells to utilize stored fats for energy. This leads to balanced triglyceride and cholesterol levels, benefiting cardiovascular health and reducing lipid-driven tissue damage.
Fasting-Mimetic Mechanisms
AMPK ingredients mimic caloric restriction's metabolic adjustments, prompting efficient energy store usage. This partial fasting effect supports healthy aging without requiring strict dietary limitations.
Autophagy & Cellular Cleanup
The Autophagy Blend contains quercetin phytosomes, spermidine, and L-ergothioneine to upregulate autophagy genes and pathways, activating the cell's recycling system to remove toxic aggregates and dysfunctional organelles.
mTOR Regulation
The blend modulates mTORC1 signaling to promote healthy balance between growth and repair phases, preventing excessive activation that speeds aging by prioritizing growth over necessary cellular maintenance.
NAD⁺ & Sirtuin Activation
Niacinamide supports NAD⁺ availability for sirtuin enzymes that maintain genomic stability, preserving efficient energy metabolism and facilitating DNA repair processes fundamental to healthy aging.
Mitochondrial Function
Antioxidant-rich ingredients reduce reactive oxygen species to protect mitochondrial membranes from oxidative damage, improving endurance, energy levels, and overall metabolic flexibility.
Inflammatory Pathway Control
Polyphenols and bioactive compounds moderate inflammatory pathways like NF-κB, reducing chronic "inflammaging" stress that erodes tissue function and accelerates cellular damage.
Insulin/IGF-1 Signaling
AMPK enhances insulin sensitivity by promoting glucose transporter movement to cell surfaces, lowering circulating glucose and insulin levels to reduce pancreatic stress and improve metabolic health.
Inflammatory & Oxidative Stress
AMPK downregulates pro-inflammatory pathways like NF-κB while complementary polyphenols provide antioxidants that reduce reactive oxygen species, maintaining tissue function and slowing age-related inflammation.
Lipid Metabolism
AMPK boosts fatty acid oxidation, pushing cells to utilize stored fats for energy. This leads to balanced triglyceride and cholesterol levels, benefiting cardiovascular health and reducing lipid-driven tissue damage.
Fasting-Mimetic Mechanisms
AMPK ingredients mimic caloric restriction's metabolic adjustments, prompting efficient energy store usage. This partial fasting effect supports healthy aging without requiring strict dietary limitations.
Autophagy & Cellular Cleanup
The Autophagy Blend contains quercetin phytosomes, spermidine, and L-ergothioneine to upregulate autophagy genes and pathways, activating the cell's recycling system to remove toxic aggregates and dysfunctional organelles.
mTOR Regulation
The blend modulates mTORC1 signaling to promote healthy balance between growth and repair phases, preventing excessive activation that speeds aging by prioritizing growth over necessary cellular maintenance.
NAD⁺ & Sirtuin Activation
Niacinamide supports NAD⁺ availability for sirtuin enzymes that maintain genomic stability, preserving efficient energy metabolism and facilitating DNA repair processes fundamental to healthy aging.
Mitochondrial Function
Antioxidant-rich ingredients reduce reactive oxygen species to protect mitochondrial membranes from oxidative damage, improving endurance, energy levels, and overall metabolic flexibility.
Inflammatory Pathway Control
Polyphenols and bioactive compounds moderate inflammatory pathways like NF-κB, reducing chronic "inflammaging" stress that erodes tissue function and accelerates cellular damage.
Insulin/IGF-1 Signaling
AMPK enhances insulin sensitivity by promoting glucose transporter movement to cell surfaces, lowering circulating glucose and insulin levels to reduce pancreatic stress and improve metabolic health.
Inflammatory & Oxidative Stress
AMPK downregulates pro-inflammatory pathways like NF-κB while complementary polyphenols provide antioxidants that reduce reactive oxygen species, maintaining tissue function and slowing age-related inflammation.
Lipid Metabolism
AMPK boosts fatty acid oxidation, pushing cells to utilize stored fats for energy. This leads to balanced triglyceride and cholesterol levels, benefiting cardiovascular health and reducing lipid-driven tissue damage.
Fasting-Mimetic Mechanisms
AMPK ingredients mimic caloric restriction's metabolic adjustments, prompting efficient energy store usage. This partial fasting effect supports healthy aging without requiring strict dietary limitations.
Autophagy & Cellular Cleanup
The Autophagy Blend contains quercetin phytosomes, spermidine, and L-ergothioneine to upregulate autophagy genes and pathways, activating the cell's recycling system to remove toxic aggregates and dysfunctional organelles.
mTOR Regulation
The blend modulates mTORC1 signaling to promote healthy balance between growth and repair phases, preventing excessive activation that speeds aging by prioritizing growth over necessary cellular maintenance.
NAD⁺ & Sirtuin Activation
Niacinamide supports NAD⁺ availability for sirtuin enzymes that maintain genomic stability, preserving efficient energy metabolism and facilitating DNA repair processes fundamental to healthy aging.
Mitochondrial Function
Antioxidant-rich ingredients reduce reactive oxygen species to protect mitochondrial membranes from oxidative damage, improving endurance, energy levels, and overall metabolic flexibility.
Inflammatory Pathway Control
Polyphenols and bioactive compounds moderate inflammatory pathways like NF-κB, reducing chronic "inflammaging" stress that erodes tissue function and accelerates cellular damage.
renewal system
Cellular Renewal Stack activates dual renewal pathways
Included with Cellular Renewal Stack
When you sign up with us we work together to create a personalized protocol using the latest innovative medicine, practicing physicians, and flexible care based around real data and plan-included testing.
When you sign up with us we work together to create a personalized protocol using the latest innovative medicine, practicing physicians, and flexible care based around real data and plan-included testing.
Frequently asked questions
The Autophagy Blend helps clear cellular waste and downregulate mTOR for deep cellular repair. The AMPK Blend re-energizes metabolism and enhances fat oxidation, driving metabolic optimization in the second phase.
A science-backed longevity protocol that alternates between Autophagy and AMPK blends to promote cellular repair, metabolic optimization, and healthy aging.
It’s ideal for individuals looking to improve energy, reduce inflammation, support mitochondrial function, and maintain long-term metabolic health—whether you're starting your longevity journey or enhancing other therapies like Rapamycin or Metformin.
Some users feel improved energy, focus, or stamina within a few weeks. Measurable changes in metabolic health, inflammation, or recovery may take 1–3 months of consistent cycling.
It combines two key longevity mechanisms: autophagy (to clear out damaged proteins and cellular waste) and AMPK activation (to restore energy and metabolic balance). This dual-phase approach helps regulate mTOR, support NAD+ levels, and reduce cellular stress over time.
Yes. The protocol is designed to cycle key ingredients to reduce the risk of adaptation and support ongoing cellular responsiveness. All components are third-party tested and manufactured in a cGMP facility.
Not required—but benefits may be amplified by intermittent fasting, time-restricted eating, or a Mediterranean-style diet. Staying hydrated and avoiding excess sugar supports optimal results.
Yes. The Cellular Renewal Stack is designed to complement therapies like Rapamycin, Metformin, or SGLT2 inhibitors by targeting parallel metabolic and cellular pathways.
The Autophagy Blend helps clear cellular waste and downregulate mTOR for deep cellular repair. The AMPK Blend re-energizes metabolism and enhances fat oxidation, driving metabolic optimization in the second phase.
A science-backed longevity protocol that alternates between Autophagy and AMPK blends to promote cellular repair, metabolic optimization, and healthy aging.
It’s ideal for individuals looking to improve energy, reduce inflammation, support mitochondrial function, and maintain long-term metabolic health—whether you're starting your longevity journey or enhancing other therapies like Rapamycin or Metformin.
Some users feel improved energy, focus, or stamina within a few weeks. Measurable changes in metabolic health, inflammation, or recovery may take 1–3 months of consistent cycling.
It combines two key longevity mechanisms: autophagy (to clear out damaged proteins and cellular waste) and AMPK activation (to restore energy and metabolic balance). This dual-phase approach helps regulate mTOR, support NAD+ levels, and reduce cellular stress over time.
Yes. The protocol is designed to cycle key ingredients to reduce the risk of adaptation and support ongoing cellular responsiveness. All components are third-party tested and manufactured in a cGMP facility.
Not required—but benefits may be amplified by intermittent fasting, time-restricted eating, or a Mediterranean-style diet. Staying hydrated and avoiding excess sugar supports optimal results.
Yes. The Cellular Renewal Stack is designed to complement therapies like Rapamycin, Metformin, or SGLT2 inhibitors by targeting parallel metabolic and cellular pathways.
Reviews
96 reviews
Healthspan is amazing!!!
Kristen was fantastic …she was kind, informative and professional. She helped me in my journey to Health and longevity! Thank you!!
Healthspan continues to be cutting edge
Healthspan continues to be cutting edge with regard to health and longevity. Brandon was knowledgeable and supportive. The details of the study were explained well and in detail.
Great experience with Healthspan
I’ve had a great experience with Healthspan. All of the representatives have been extremely responsive when sending messages on the portal, and I had a great call reviewing my initial labs with Brandon Fell who was extremely knowledgeable and courteous. I’ve started the Rapamycin and Acarbose protocol, and I’m looking forward to seeing what my updated labs will show in a couple months!